Secondary metabolites are not essential for the growth of microorganisms, but they play a
critical role in how microbes interact with their surroundings. In addition to this important …

ANALYSIS AND ENGINEERING OF METABOLIC NETWORKS Page 1 FERMENTATION
ANALYSIS AND ENGINEERING OF METABOLIC NETWORKS Nicholas D LINDLEY …

In this work we present a multi-level optimization method based on flux balance analysis
models (FBA) for identifying meaningful biological objective functions that drive the cell's …

Plant growth-promoting bacteria are well known to produce various bacterial secondary
metabolites (BSM) which are much diversified in their origin and structure. These …

The state of the art tools for modeling metabolism, typically used in the domain of metabolic
engineering, were reviewed. The tools considered are stoichiometric network analysis …

Metabolic engineering is an integrating methodology of analysis and synthesis for the
improvement of flux distribution of metabolic pathways in complicated bioprocesses, which …

Metabolic engineering principles have long been applied to explore the metabolic networks
of complex microbial cell factories under a variety of environmental constraints for effective …

The intracellular metabolic fluxes can be calculated by metabolic flux analysis, which uses a
stoichiometric model for the intracellulal reactions along with mass balances around the …

Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …

With the rapid growth of micro-organism metabolic networks, acquiring the intracellular
concentration of microorganisms' metabolites accurately in large-batch is critical to the …