Recent studies demonstrate that the factors involved in mRNA processing specify the fate of
a transcript. The mRNA is either committed for export to the cytoplasm or accumulates in the …

In eukaryotes, the production of mature messenger RNA that exits the nucleus to be
translated into protein in the cytoplasm requires precise and extensive modification of the …

In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on
messenger RNA (mRNA) functionality. It is well established that control of protein-coding …

Proper regulation of mRNA production in the nucleus is critical for the maintenance of
cellular homoeostasis during adaptation to internal and environmental cues. Over the past …

Nuclear export of mRNA is a central step in gene expression that shows extensive coupling
to transcription and transcript processing. However, little is known about the fate of mRNA …

mRNAs are transported from the nucleus to the cytoplasm by a machinery conserved from
yeast to humans. Previous studies showed that mRNA export factors are loaded on nascent …

Several aspects of eukaryotic mRNA processing are linked to transcription. In
Saccharomyces cerevisiae, overexpression of the mRNA export factor Sub2p suppresses …

The majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast
amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The …

In eukaryotic cells, primary transcripts are processed and bound by proteins before export to
the cytoplasm. Nuclear production of export-competent messenger ribonucleoprotein …

The subcellular localization of RNAs correlates with their function and how they are
regulated. Most protein-coding mRNAs are exported into the cytoplasm for protein synthesis …