Background Aspirin-exacerbated respiratory disease (AERD) is an endotype of severe and
eosinophilic adult asthma characterized by chronic rhinosinusitis with nasal polyps and …

Background Genetic polymorphism determines agonist-induced down-regulation and
desensitization ofβ 2-adrenoceptors. Objectives The aim of the present study was to …

The aim of this study was to analyse any potential correlation between b2 adrenoceptor
(ADRB2) polymorphism and asthma risk and prognosis. The ADRB2 gene contains …

BACKGROUND: β2-Adrenergic receptor (B2AR) polymorphisms have been associated with
a variety of asthma-related phenotypes, but association results have been inconsistent …

Background We have previously reported a relationship between increased airway
responsiveness (AR) in infancy and reduced childhood lung function. Objective The current …

Background: An interindividual variability in response to short-acting bronchodilator drugs
(short-acting inhaled β2-agonists, SABA) exists and this is linked in part to genetic factors …

Background: Several polymorphisms of the β2-adrenergic receptor (ADRB2) gene have
been identified. There is mounting evidence that these polymorphisms are associated with …

Rationale: Genetic variation of the β2-adrenoceptor (ADRB2) influences receptor function in
vitro. There are reports that, in vivo, bronchodilator response is related to ADRB2 genotype …

A recent status on asthmaticus multiple case report by Beute demonstrated the beneficial
effects of phosphodiesterase III (PDE3) and phosphodiesterase IV (PDE4) inhibition. This …

Objective We tested the hypothesis that patients with difficult asthma have an increased
frequency of certain genotypes that predispose them to asthma exacerbations and poor …