Cite this as: LP Chung, G. Waterer and PJ Thompson, Clinical & Experimental Allergy, 2011
(41) 312–326. Summary Adrenergic β2 receptor (ADRβ2) agonists are widely used in …

Background It has long been recognized that many children with asthma outgrow the
disease after the onset of puberty, but little is known about genetic factors influencing this …

BACKGROUND: Cyclic AMP (cAMP) signaling modulates functions of inflammatory cells
involved in the pathogenesis of asthma, and type 4 cAMP-specific phosphodiesterases …

A different approach towards determining the role of PDE4 subtypes was taken by Marco
Conti (Stanford University School of Medicine, Stanford, CA, USA), who reported on the …

BACKGROUND: Inhaled corticosteroids (ICSs) are considered first-line treatment for
persistent asthma, yet there is significant variability in treatment response. Dual-specificity …

Abstract Background The polymorphism Arg16 in β2‐adrenergic receptor (ADRB2) gene
has been associated with an increased risk of exacerbations in asthmatic children treated …

OBJECTIVE: To determine the relationship between allelic variations in genes involved in
fluticasone propionate (FP) metabolism and asthma control among children with asthma …

Airway hyperresponsiveness (AHR) is a hallmark feature in asthma characterized by
exaggerated airway contractile response to stimuli due to increased airway sensitivity and …

Background: The association of haplotype combinations of polymorphisms at positions 16
and 27 of the β 2-adrenergic receptor (ADRB2) gene and the risk of asthma exacerbations …

Repository at www. jacionline. org), all of which validated the original findings. Furthermore,
we examined the evidence for association to SNPs within PDE11A in 5 independent …