Background Several studies have suggested that after regular use of short acting β2‐
agonists the bronchodilator effect of the drug may decline and this condition would be …

Background During severe exacerbations, asthmatic children vary significantly in their
response to high‐dose continuous β2‐adrenergic receptor (ADRβ2) agonist therapy …

Background: The β 2-adrenergic receptor gene is a typical candidate for the study of genetic
polymorphism. Many patients with asthma do not respond to β2-agonist; in addition, a wide …

14 Koppelman GH, Stine OC, Xu J, et al. Genome-wide search for atopy susceptibility genes
in Dutch families with asthma. J Allergy Clin Immunol 2002; 109: 498–506 15 Xu X, Fang Z …

Aims: To investigate the effects of genetic variation on treatment response to asthma
medication in children and to identify (profiles of) SNPs that characterize response …

The aim of the present study was to investigate bronchoprotective sensitivity in patients
receiving regular treatment with short-and long-acting β2-agonists and to evaluate any …

Aspirin ingestion is a common precipitating factor of life-threatening asthma attacks,
requiring some patients to undergo mechanical ventilation. The gene, D-tyrosyl-tRNA …

Asthma is a common chronic condition in children, where the response to treatment can be
heterogeneous within a population. Genetic variations may partly explain the inconsistent …

The idea that an abnormality in the β 2-adrenergic receptor contributes to asthma has been
a long-standing hypothesis. Since the discovery of functionally relevant polymorphisms in …

Aspirin-intolerant asthma (AIA) is a subtype of bronchial asthma characterized by
development of bronchoconstriction evoked by non-steroidal anti-inflammatory drugs …