Hepatitis C virus (HCV) currently infects over 185 million individuals around the world. Its
persistence causes infected individuals to enter a chronic phase where their condition can …

Hepatitis C virus (HCV) infection is a serious and growing threat to human health. The
current treatment provides limited efficacy and is poorly tolerated, highlighting the urgent …

Abstract The 9.6 kb plus-strand RNA genome of HCV encodes a long polyprotein precursor
of~ 3,000 amino acids, which is processed by cellular and viral proteases to 10 individual …

Chronic hepatitis C virus infection is a global problem worldwide due to the lack of an
effective therapy (the current standard of care treatment is effective in about 40-50% of the …

New treatments for HCV (Hepatitis C virus) infections are likely to arise from inhibition of the
essential, virally-encoded enzymes. These targets include the serine protease required for …

Dissertations from the Faculty of Pharmacy 282. 79 pp. Uppsala. ISBN 91-554-5538-7.
Hepatitis C Virus (HCV) is the leading cause of chronic liver disease worldwide as well as …

Publisher Summary Hepatitis C virus (HCV) infection continues to be a serious disease with
a large unmet clinical need. There has been substantial progress in the HCV virology and in …

Hepatitis C virus (HCV) infection is a serious cause of chronic liver disease worldwide and
afflicts> 170 million people. The HCV-encoded NS3 protease is essential for viral replication …

The hepatitis C virus (HCV) epidemic represents a significant unmet medical need. Current
treatment is arduous and less than 50% effective. Indeed, interferon-alpha treatment is so …

Today, we are witnessing a new era for the treatment of hepatitis C with excellent rates of
virologic response and very good safety profiles. Among the many classes of direct‐acting …