Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases

MJ Khoury, L Bertram, P Boffetta… - American journal of …, 2009 - academic.oup.com
Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …

Genome-wide association studies and beyond

JS Witte - Annual review of public health, 2010 - annualreviews.org
Genome-wide association studies (GWAS) provide an important avenue for undertaking an
agnostic evaluation of the association between common genetic variants and risk of …

Genomewide association studies and human disease

J Hardy, A Singleton - New England Journal of Medicine, 2009 - Mass Medical Soc
Genomewide Association Studies and Human Disease | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

A road map for efficient and reliable human genome epidemiology

JPA Ioannidis, M Gwinn, J Little, JPT Higgins… - Nature Genetics, 2006 - nature.com
Networks of investigators have begun sharing best practices, tools and methods for analysis
of associations between genetic variation and common diseases. A Network of Investigator …

Collaborative Genome-Wide Association Studies of Diverse Diseases: Programs of the NHGRI's Office of Population Genomics

TA Manolio - Pharmacogenomics, 2009 - Taylor & Francis
In the past 3 years, genome-wide association (GWA) studies have revolutionized the
discovery of genetic variants associated with complex diseases. These studies present …

Genome-wide association studies

A Dehghan - Genetic Epidemiology: Methods and Protocols, 2018 - Springer
Genetic association studies have made a major contribution to our understanding of the
genetics of complex disorders over the last 10 years through genome-wide association …

Genomewide association studies—illuminating biologic pathways

JN Hirschhorn - New England journal of medicine, 2009 - Mass Medical Soc
Genomewide Association Studies — Illuminating Biologic Pathways | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Genomewide association studies and assessment of the risk of disease

TA Manolio - New England journal of medicine, 2010 - Mass Medical Soc
Over the past 5 years, genomewide association studies have yielded a wealth of insight into
genes and chromosomal loci that contribute to susceptibility to disease. This article, the …

Genome-wide association studies and human disease: from trickle to flood

PM Visscher, GW Montgomery - Jama, 2009 - jamanetwork.com
MANY COMMON COMPLEX DISEASES SUCH AS hypertension, diabetes, coronary heart
dis-ease, psychiatric disorders, and some cancers have a genetic etiology. Despite …

Discovery properties of genome-wide association signals from cumulatively combined data sets

TV Pereira, NA Patsopoulos, G Salanti… - American journal of …, 2009 - academic.oup.com
Genetic effects for common variants affecting complex disease risk are subtle. Single
genome-wide association (GWA) studies are typically underpowered to detect these effects …