Sphingolipids are a diverse class of signaling molecules implicated in many important
aspects of cellular biology, including growth, differentiation, apoptosis, and autophagy …

Sphingolipids form a broad class of lipids with diverse functions ranging from membrane
constituents to intracellular second messengers and extracellular mediators. They can be …

Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …

Chronic obstructive pulmonary disease (COPD) includes a spectrum of conditions that have
in common varying degrees of airflow obstruction, such as chronic bronchitis and …

Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and
the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many …

Sphingolipids play key roles in cancer, yet our current understanding of sphingolipid
function in lung cancer is limited to a few key players. The best characterized of these are …

Sphingolipids, universal components of biological membranes of all eukaryotic organisms,
from yeasts to mammals, in addition of playing a structural role, also play an important part of …

Sphingolipids comprise a class of bioactive lipids that are involved in a variety of
pathophysiologic processes, including cell death and survival. Ceramide and sphingosine-1 …

Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …

Sphingolipids are important bioactive lipids that not only play an important role in
maintaining the barrier function and fluidity of cell membranes but also regulate multiple …