Complement activation is critical in the development of local mucosal damage and
inflammation as well as of remote organ injury after mesenteric ischemia/reperfusion. To …

Intestinal ischemia followed by reperfusion leads to local and remote organ injury attributed
to inflammatory response during the reperfusion phase. The extent to which ischemia …

C3a is a key complement activation fragment, yet its neutrophil-expressed receptor (C3aR)
still has no clearly defined role. In this study, we used a neutrophil-dependent mouse model …

C5 is critical in the development of local mucosal damage and inflammation as well as in the
development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the …

Background CD31 is a key transmembrane neutrophil immunoregulatory receptor.
Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage …

Background and Aims: Complement activation plays an important role in the local
pathogenesis of ischemia/reperfusion (I/R) injury. We investigated the action of anti-C5 …

Deficiency in the membrane-bound complement regulators CD55 and CD59 exacerbates
renal ischemia-reperfusion injury (IRI) in mouse models, but the effect of increasing CD55 …

The complement C5a pathway has been shown to be an important mediator of inflammation
and tissue injury. To further understand the role of C5a receptor (C5aR) pathway in …

There is accumulating evidence in humans and in experimental sepsis that robust activation
of the complement system occurs along with development of defects in the innate immune …

Neutrophil infiltration to ischemic tissues following reperfusion worsens injury. A key driver of
neutrophil recruitment and activation is the complement factor C5a, which signals through …