This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

This paper is the outcome of the fourth UC Davis Systems Approach to Understanding
Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a biannual event …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

The development of novel drugs specifically directed at the ion channels underlying
particular features of cardiac action potential (AP) initiation, recovery, and refractoriness …

Potassium channel currents are important in maintaining the normal electrical activity in
most excitable cells. This family of channels controls the cell resting potential and action …

Potassium channels (K+) are membrane-spanning proteins which serve many important
functions and are becoming a hot topic in physiology. K+ channels determine or modulate …

Cardiac K+ channels are cardiomyocyte membrane proteins that regulate K+ ion flow across
the cell membrane on the electrochemical gradient and determine the resting membrane …

Cardiomyocytes are endowed with a complex repertoire of ion channels, responsible for the
generation of action potentials (APs), travelling waves of electrical excitation, propagating …

Myocardial K+ currents function to control resting membrane potentials, the heights and
durations of action potentials, and refractoriness and automaticity. They are important targets …

The sodium-potassium pump is widely recognized as the principal mechanism for active ion
transport across the cellular membrane of cardiac tissue, being responsible for the creation …