In this paper, we examine the usefulness of recombination from two points of view. First, the
problem of crossover disruption is investigated. This is done by comparing two Genetic …

The concept of fitness is introduced, and a simple derivation of the Fundamental Theorem of
Natural Selection (which states that the average fitness of a population increases if its …

We study biological evolution in a high-dimensional genotype space in the regime of rare
mutations and strong selection. The population performs an uphill walk which terminates at …

The basic evolutionary operators of mutation and natural selection do not perform well, in
the sense of translating a population to which they are applied over a space of genotypes to …

The evolution of RNA molecules in replication assays, viroids and RNA viruses can be
viewed as an adaptation process on a 'fitness' landscape. The dynamics of evolution is …

We introduce a model of evolution on a fitness landscape possessing a tunable degree of
neutrality. The model allows us to study the general properties of molecular species …

The fitness effects of mutations on a given genotype are rarely constant across environments
to which this genotype is more or less adapted, that is, between more or less stressful …

The idea of adaptive walks on fitness landscapes as a means of studying evolutionary
processes on large time scales is extended to fitness landscapes that are slowly changing …

Following infection to a host, some pathogens repeatedly alter their antigen expression, and
thereby escape the immune defense (antigen drift/switching). This paper examines the …

The interplay of ruggedness and neutrality in fitness landscapes plays an important role in
explaining the dynamics of evolutionary adaptation. While various measures of ruggedness …