DNA methylation is one of the most important epigenetic mechanisms in regulating gene
expression. Genome hypermethylation has been proposed as a critical mechanism in …

Altered genome methylation is a hallmark of human malignancies. In this study, high-
throughput analyses of concordant gene methylation and expression events were performed …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

Background Aberrant DNA methylation may promote prostate carcinogenesis. We
investigated epigenome‐wide DNA methylation profiles in prostate cancer (PCa) compared …

Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of
prostate cancer progression. We mapped the global DNA methylation patterns in select …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

DNA methylation of promoter CpG islands is strongly associated with gene silencing and is
known as a frequent cause of loss of expression of tumor suppressor genes, as well as other …

Many differentially methylated genes have been identified in prostate cancer (PCa),
primarily using candidate gene-based assays. Recently, several global DNA methylation …

We performed a global methylation profiling assay on 1505 CpG sites across 807 genes to
characterize DNA methylation patterns in pancreatic cancer genome. We found 289 CpG …

Background Promoter and 5′ end methylation regulation of tumour suppressor genes is a
common feature of many cancers. Such occurrences often lead to the silencing of these key …