Background Activation of the mTOR pathway has been observed in thyroid cancer, but the
biologic consequences regarding tumor behavior and patient prognosis remain poorly …

Simple Summary Papillary thyroid cancer (PTC) comprises approximately 80% of all thyroid
malignancies. The field of PTC genetics and cancerogenesis remains undetermined …

The mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer
(TC). We previously demonstrated that phospho-mTOR expression is associated with tumor …

BACKGROUND: Because mammalian target of rapamycin (mTOR) may be involved in
thyroid carcinogenesis, we investigated the expression and activation patterns of mTOR …

Purpose: Understanding the molecular pathogenesis of medullary thyroid carcinoma (MTC)
is prerequisite to the design of targeted therapies for patients with advanced disease …

The mammalian target of rapamycin (mTOR) signaling cascade is a key regulatory pathway
controlling initiation of messenger RNA in mammalian cells. Although dysregulation of …

We used morphoproteomics to investigate mammalian target of rapamycin (MTOR)
signaling pathway in papillary thyroid carcinomas and correlated the results with …

Context: Thyroid growth is regulated by TSH and requires mammalian target of rapamycin
(mTOR). Thyroid cancers frequently exhibit mutations in MAPK and/or phosphoinositol-3 …

Objective Rearranged during transfection (RET) mutations are well-known genetic events in
sporadic and familial medullary thyroid carcinoma (FMTC). The presence of RAS mutations …

Context: There are several genetic and molecular evidences suggesting dysregulation of the
mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia. Activation of the …