Passive immunotherapy, including adoptive T-cell therapy and antibody therapy, has shown
encouraging results in cancer treatment lately. However, active immunotherapy of solid …

The dichotomy of immunology into innate and adaptive immunity has created conceptual
barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging …

Immunity to infectious agents involves a coordinated response of innate and adaptive
immune cells working in concert, with many feed-forward and regulatory interactions …

Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …

Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector
immune response are two of the emerging hallmarks required for oncogenesis and cancer …

Breaking down the barriers to cancer immunotherapy | Nature Immunology Skip to main
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The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive
and innate immune cells that have tumor-promoting and anti-tumor effects. There is still …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …