[HTML][HTML] Translational modeling of psychomotor function in normal and AD-pathological aging with special concerns on the effects of social isolation

L Castillo-Mariqueo, L Giménez-Llort - Frontiers in Aging, 2021 - frontiersin.org
One year after the start of the COVID-19 pandemic, its secondary impacts can be globally
observed. Some of them result from physical distancing and severe social contact …

[HTML][HTML] Impact of social isolation on the behavioral, functional profiles, and hippocampal atrophy asymmetry in dementia in times of coronavirus pandemic (COVID-19 …

A Muntsant, L Giménez-Llort - Frontiers in psychiatry, 2020 - frontiersin.org
The impact of COVID-19 on the elderly is devastating, and nursing homes are struggling to
provide the best care to the most fragile. The urgency and severity of the pandemic forces …

419-Brain atrophy asymmetry in dementia is worsened by social isolation: A translational neuroscience approach in times of coronavirus pandemic (COVID-19)

A Muntsant-Soria, L Giménez-Llort - International Psychogeriatrics, 2020 - cambridge.org
The coronavirus pandemic (COVID-19) that has ravaged the entire world presents the most
dramatic scenarios in the most vulnerable populations, with exacerbated focus on the …

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

L Gimenez-Llort, D Alveal-Mellado - Frontiers in Behavioral …, 2021 - frontiersin.org
The severity of this pandemic's scenarios will leave significant psychological traces in low
resistant and resilient individuals. Increased incidence of depression, anxiety, obsessive …

Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages …

A Muntsant, MM Castillo-Ruiz… - International journal of …, 2023 - mdpi.com
Pre-clinical research in aging is hampered by the scarcity of studies modeling its
heterogeneity and complexity forged by pathophysiological conditions throughout the life …

Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social …

A Muntsant, L Giménez-Llort - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Coping with emotional stressors strongly impacts older people due to their age-related
impaired neuroendocrine and immune systems. Elevated cortisol levels seem to be …

Vibrating tail, digging, body/face interaction, and lack of barbering: sex-dependent behavioral signatures of social dysfunction in 3xTg-AD mice as compared to mice …

V Torres-Lista, L Giménez-Llort - Journal of Alzheimer's …, 2019 - content.iospress.com
Modeling of Alzheimer's disease (AD), classically focused on the subject-environment
interaction, foresees current social neuroscience efforts as improving the predictive validity …

[HTML][HTML] Age, Sex and Alzheimer's disease: A longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in …

AJ Barber, CL Del Genio, AB Swain, EM Pizzi… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background Aging and sex are major risk factors for developing late-onset Alzheimer's
disease. Compared to men, women are not only nearly twice as likely to develop …

Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) …

L Castillo-Mariqueo, L Giménez-Llort - Biomedicines, 2022 - mdpi.com
Longitudinal approaches for disease-monitoring in old animals face survival and frailty
limitations, but also assessment and re-test bias on genotype and sex effects. The present …

[HTML][HTML] Unwanted exacerbation of the Immune response in neurodegenerative disease: a Time to review the impact

AOF Leite, J Bento Torres Neto… - Frontiers in Cellular …, 2021 - frontiersin.org
The COVID-19 pandemic imposed a series of behavioral changes that resulted in increased
social isolation and a more sedentary life for many across all age groups, but, above all, for …