Animal models to study the neurological manifestations of the post-COVID-19 condition

C Usai, L Mateu, C Brander, J Vergara-Alert, J Segalés - Lab Animal, 2023 - nature.com
More than 40% of individuals infected by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) have experienced persistent or relapsing multi-systemic symptoms months …

The virtual aging brain: a model-driven explanation for cognitive decline in older subjects

M Lavanga, J Stumme, BH Yalcinkaya, J Fousek… - bioRxiv, 2022 - biorxiv.org
Healthy aging is accompanied by heterogeneous decline of cognitive abilities among
individuals, especially during senescence. The mechanisms of this variability are not …

[引用][C] P1–124: Modeling neuropsychiatric symptoms of Alzheimer's dementia in 3xTgAD mice

L Gimenez-Llort, G Blazquez, T Canete… - Alzheimer's & …, 2006 - Wiley Online Library
Background Neuropsychiatric symptoms of dementia have a high prevalence among AD
patients and are the most important source of distress and burden for caregivers. Paranoid …

Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer's disease

A Altunkaya, C Deichsel, M Kreuzer, DM Nguyen… - Scientific Reports, 2024 - nature.com
Demographic changes will expand the number of senior citizens suffering from Alzheimer's
disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset …

Sex-and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice

D Alveal-Mellado, L Castillo-Mariqueo… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) patients suffer from circadian rhythm alterations affecting their
daily physical activity patterns with less willingness to perform a voluntary exercise. In …

[HTML][HTML] A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

J Wezeman, M Darvas, N Postupna, J Klug… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The process of aging is defined by the breakdown of critical maintenance pathways leading
to an accumulation of damage and its associated phenotypes. Aging affects many systems …

The effects of aging on the BTBR mouse model of autism spectrum disorder

JM Jasien, CM Daimon, R Wang, BK Shapiro… - Frontiers in aging …, 2014 - frontiersin.org
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder
characterized by alterations in social functioning, communicative abilities, and engagement …

Understanding the heterogeneity and spatial brain environment of neurodegenerative diseases through conventional and future methods

C Li, ML Dubbelaar, X Zhang, JC Zheng - Frontiers in Cellular …, 2023 - frontiersin.org
Neurodegenerative diseases (ND) are characterized by progressive cognitive, psychiatric,
and motor deficits due to neuronal loss of the affected brain regions (Cummings and Pillai …

Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice

M Mainardi, A Di Garbo, M Caleo, N Berardi… - Frontiers in aging …, 2014 - frontiersin.org
Brain aging is characterized by global changes which are thought to underlie age-related
cognitive decline. These include variations in brain activity and the progressive increase in …

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice

V Gatta, M D'Aurora, A Granzotto, L Stuppia… - Cell death & …, 2014 - nature.com
Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic
profile that is still not completely understood. In this study, using a whole gene microarray …