Animal models to study the neurological manifestations of the post-COVID-19 condition
More than 40% of individuals infected by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) have experienced persistent or relapsing multi-systemic symptoms months …
(SARS-CoV-2) have experienced persistent or relapsing multi-systemic symptoms months …
The virtual aging brain: a model-driven explanation for cognitive decline in older subjects
M Lavanga, J Stumme, BH Yalcinkaya, J Fousek… - bioRxiv, 2022 - biorxiv.org
Healthy aging is accompanied by heterogeneous decline of cognitive abilities among
individuals, especially during senescence. The mechanisms of this variability are not …
individuals, especially during senescence. The mechanisms of this variability are not …
[引用][C] P1–124: Modeling neuropsychiatric symptoms of Alzheimer's dementia in 3xTgAD mice
L Gimenez-Llort, G Blazquez, T Canete… - Alzheimer's & …, 2006 - Wiley Online Library
Background Neuropsychiatric symptoms of dementia have a high prevalence among AD
patients and are the most important source of distress and burden for caregivers. Paranoid …
patients and are the most important source of distress and burden for caregivers. Paranoid …
Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer's disease
Demographic changes will expand the number of senior citizens suffering from Alzheimer's
disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset …
disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset …
Sex-and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice
D Alveal-Mellado, L Castillo-Mariqueo… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) patients suffer from circadian rhythm alterations affecting their
daily physical activity patterns with less willingness to perform a voluntary exercise. In …
daily physical activity patterns with less willingness to perform a voluntary exercise. In …
[HTML][HTML] A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice
J Wezeman, M Darvas, N Postupna, J Klug… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The process of aging is defined by the breakdown of critical maintenance pathways leading
to an accumulation of damage and its associated phenotypes. Aging affects many systems …
to an accumulation of damage and its associated phenotypes. Aging affects many systems …
The effects of aging on the BTBR mouse model of autism spectrum disorder
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder
characterized by alterations in social functioning, communicative abilities, and engagement …
characterized by alterations in social functioning, communicative abilities, and engagement …
Understanding the heterogeneity and spatial brain environment of neurodegenerative diseases through conventional and future methods
C Li, ML Dubbelaar, X Zhang, JC Zheng - Frontiers in Cellular …, 2023 - frontiersin.org
Neurodegenerative diseases (ND) are characterized by progressive cognitive, psychiatric,
and motor deficits due to neuronal loss of the affected brain regions (Cummings and Pillai …
and motor deficits due to neuronal loss of the affected brain regions (Cummings and Pillai …
Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice
Brain aging is characterized by global changes which are thought to underlie age-related
cognitive decline. These include variations in brain activity and the progressive increase in …
cognitive decline. These include variations in brain activity and the progressive increase in …
Early and sustained altered expression of aging-related genes in young 3xTg-AD mice
Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic
profile that is still not completely understood. In this study, using a whole gene microarray …
profile that is still not completely understood. In this study, using a whole gene microarray …