Identification of a Grga-Euo-Hrca transcriptional regulatory network in Chlamydia

W Wurihan, Y Zou, AM Weber, K Weldon, Y Huang… - Msystems, 2021 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium whose unique developmental
cycle consists of an infectious elementary body and a replicative reticulate body …

Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

B Lu, Y Wang, W Wurihan, A Cheng, S Yeung… - Mbio, 2024 - Am Soc Microbiol
Chlamydia, an obligate intracellular bacterial pathogen, has a unique developmental cycle
involving the differentiation of invading elementary bodies (EBs) to noninfectious reticulate …

GrgA overexpression inhibits Chlamydia trachomatis growth through sigma66-and sigma28-dependent mechanisms

W Wurihan, AM Weber, Z Gong, Z Lou, S Sun… - Microbial …, 2021 - Elsevier
The obligate intracellular bacterium Chlamydia trachomatis is an important human pathogen
with a biphasic developmental cycle comprised of an infectious elementary body (EB) and a …

Role for GrgA in Regulation of σ28-Dependent Transcription in the Obligate Intracellular Bacterial Pathogen Chlamydia trachomatis

M Desai, W Wurihan, R Di, JD Fondell… - Journal of …, 2018 - Am Soc Microbiol
The obligate intracellular bacterial pathogen Chlamydia trachomatis has a unique
developmental cycle consisting of two contrasting cellular forms. Whereas the primary …

Euo is a developmental regulator that represses late genes and activates midcycle genes in Chlamydia trachomatis

OR Hakiem, SMA Rizvi, C Ramirez, M Tan - Mbio, 2023 - Am Soc Microbiol
The pathogenic bacterium Chlamydia reproduces via an unusual intracellular
developmental cycle in which it converts from a dividing form (reticulate body or RB) to an …

Diversity of σ66-Specific Promoters Contributes to Regulation of Developmental Gene Expression in Chlamydia trachomatis

L Shen, L Gao, Y Zhang, Z Hua - Journal of Bacteriology, 2023 - Am Soc Microbiol
Promoter recognition by the RNA polymerase (RNAP) holoenzyme is a key step in gene
regulation. In Chlamydia trachomatis, a medically important obligate intracellular bacterium …

Quantifying promoter activity during the developmental cycle of Chlamydia trachomatis

Y Cong, L Gao, Y Zhang, Y Xian, Z Hua, H Elaasar… - Scientific Reports, 2016 - nature.com
Chlamydia trachomatis is an important human pathogen that undergoes a characteristic
development cycle correlating with stage-specific gene expression profiles. Taking …

Chlamydial GroEL autoregulates its own expression through direct interactions with the HrcA repressor protein

AC Wilson, CC Wu, JR Yates III, M Tan - Journal of bacteriology, 2005 - Am Soc Microbiol
In the pathogenic bacterium Chlamydia trachomatis, a transcriptional repressor, HrcA,
regulates the major heat shock operons, dnaK and groE. Cellular stress causes a transient …

Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host–pathogen interactions

C Yang, L Kari, GL Sturdevant, L Song… - Pathogens and …, 2017 - academic.oup.com
Chlamydia trachomatis is an obligate intracellular pathogen characterized by a unique
biphasic developmental cycle that alternates between infectious and non-infectious …

Following the footsteps of chlamydial gene regulation

D Domman, M Horn - Molecular Biology and Evolution, 2015 - academic.oup.com
Regulation of gene expression ensures an organism responds to stimuli and undergoes
proper development. Although the regulatory networks in bacteria have been investigated in …