Synopsis Citalopram is a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor
(SSRI) which has been evaluated primarily in the treatment of major depression. In well …

Genetic polymorphisms of CYP2D6 significantly influence the efficacy and safety of some
drugs, which might cause adverse effects and therapeutic failure. We aimed at investigating …

What is known and objective Genetic variations in drug‐metabolizing enzyme genes change
drug pharmacokinetics and response. CYP 2C19 is a clinically important enzyme that …

Two methods using LC–MS/MS were validated to quantify citalopram (CTP) racemate [(R/S)‐
CTP] and the enantiomers (R)‐CTP and (S)‐CTP in human plasma, respectively. Paroxetine …

Objective: To compare the pharmacokinetics of the antidepressant citalopram and its
metabolites demethylcitalopram and didemethylcitalopram in subjects with moderate renal …

Aims To investigate pharmacokinetics of the enantiomers of citalopram (CT) and its
metabolites desmethylcitalopram (DCT) and didesmethylcitalopram (DDCT) in Swedish …

The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive
despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability …

Objectives To assess the bio-equivalence of two citalopram 40 mg tablet formulations
(Lecital of the Jordan Sweden Medical and Sterilization Co.(JOSWE) as a test product, and …

A sensitive and selective LC-MS/MS method for determination of citalopram in human
plasma was established to study the bioequivalence of different formulations containing …

Background We sought to determine whether clinical response or tolerance to the Selective
Serotonin Reuptake Inhibitor (SSRI) citalopram is associated with genetic polymorphisms in …