Abnormal accumulation of β-amyloid (Aβ) in Alzheimer's disease (AD) is associated with
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive
decline. Amyloid plaque deposits consisting specifically of β‐amyloid peptides that have …

Background Complement proteins and activation products have been found associated with
neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

This review discusses key findings indicating potential roles of the complement (C)-system
in chronic inflammation in Alzheimer's disease (AD) brain. Although there is no means to …

C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein known to be expressed in brain of Alzheimer's disease (AD) patients …

The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

A variety of inflammatory mediators including complement activation products, protease
inhibitors, and cytokines are colocalized with β-amyloid (Aβ) deposits in the Alzheimer's …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …