The drug named defibrotide (DFT) has been studied for many years. It has been shown to
possess many activities: profibrinolytic, antithrombotic–thrombolytic, antiischemic (heart …

Synopsis Defibrotide is a deoxyribonucleic acid derivative extracted from mammalian
organs, which has been developed for the treatment of a number of vascular disorders. It …

Defibrotide is the sodium salt of a polydeoxyribonucleotide extracted from mammalian
organs and prepared by controlled depolymerization of deoxyribonucleic acid (DNA). The …

Defibrotide is a polydeoxyribonucleotide sodium salt extracted from mammalian organs. Its
mean molecular weight is 15,000-30,000 daltons. Defibrotide contains aptamers, ie, single …

Defibrotide is a polydisperse oligonucleotide with antiatherosclerotic, anti-inflammatory, anti-
ischaemic, pro-fibrinolytic and antithrombotic actions without significant systemic …

Defibrotide is a single-stranded DNA fraction obtained from mammalian lung and is able to
increase prostacyclin production by endothelial cells. It has profibrinolytic and antithrombotic …

Fibrinolytic activity has been shown to be reduced in many vascular diseases, including
hepatic veno-occlusive disease after stem cell transplantation, a microangiopathy …

1 Administration of bovine thrombin (100 u kg− 1) into the carotid artery of rabbits induces a
sustained accumulation of 111Indium‐labelled platelets within the cranial vasculature over …

Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-
thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial …

An extensive study of the pharmacokinetics and the pharmacokinetics of the profibrinolytic
activity of Defibrotide (D) in the rabbit has been made. A two compartment model was used …