Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
M Avril, BR Kulasekara, SO Gose, C Rowe… - Infection and …, 2008 - Am Soc Microbiol
Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin …
[HTML][HTML] Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins
Background Pregnancy associated malaria is a severe clinical syndrome associated with
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria
M Fried, M Avril, R Chaturvedi, P Fernandez… - Infection and …, 2013 - Am Soc Microbiol
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …
[HTML][HTML] Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
[HTML][HTML] Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …
A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates
JYA Doritchamou, JP Renn, B Jenkins, A Mahamar… - Elife, 2022 - elifesciences.org
Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …
[HTML][HTML] A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria
JYA Doritchamou, R Herrera, JA Aebig… - The Journal of …, 2016 - academic.oup.com
Background. Placental malaria is caused by Plasmodium falciparum–infected erythrocytes
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …
[HTML][HTML] Identification and characterization of B-cell epitopes in the DBL4ε domain of VAR2CSA
SB Ditlev, MA Nielsen, M Resende, MØ Agerbæk… - 2012 - journals.plos.org
Malaria during pregnancy in Plasmodium falciparum endemic regions is a major cause of
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …
mortality and severe morbidity. VAR2CSA is the parasite ligand responsible for …
Immunogenicity of Duffy binding-like domains that bind chondroitin sulfate A and protection against pregnancy-associated malaria
N Bir, SS Yazdani, M Avril, C Layez, J Gysin… - Infection and …, 2006 - Am Soc Microbiol
Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is implicated
in pathological outcomes of pregnancy-associated malaria (PAM). P. falciparum isolates that …
in pathological outcomes of pregnancy-associated malaria (PAM). P. falciparum isolates that …