High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high …
YL Tutterrow, M Avril, K Singh, CA Long… - Infection and …, 2012 - Am Soc Microbiol
Placental malaria, caused by sequestration of Plasmodium falciparum-infected erythrocytes
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
in the placenta, is associated with increased risk of maternal morbidity and poor birth …
Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response …
S Dechavanne, A Srivastava, S Gangnard… - Infection and …, 2015 - Am Soc Microbiol
Plasmodium falciparum multidomain protein VAR2CSA stands today as the leading vaccine
candidate against pregnancy-associated malaria (PAM). Most of the studies aiming to …
candidate against pregnancy-associated malaria (PAM). Most of the studies aiming to …
Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay
H Obiakor, M Avril, NJ MacDonald… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
ABSTRACT VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
protein 1 (PfEMP1) family, is a leading candidate for use in vaccines to protect first-time …
[HTML][HTML] Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens
AV Oleinikov, E Rossnagle, S Francis… - The Journal of …, 2007 - academic.oup.com
Background. Plasmodium falciparum-infected erythrocytes adhere to chondroitin sulfate A
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
[HTML][HTML] Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6ε domain of VAR2CSA
C Badaut, G Bertin, T Rustico, N Fievet… - PLoS …, 2010 - journals.plos.org
Background Placental malaria is a disease linked to the sequestration of Plasmodium
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …
falciparum infected red blood cells (IRBC) in the placenta, leading to reduced materno-fetal …
[HTML][HTML] Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A
K Singh, AG Gittis, P Nguyen, DC Gowda… - Nature structural & …, 2008 - nature.com
Plasmodium falciparum–infected erythrocytes bind to chondroitin sulfate A (CSA) in the
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …
placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane …
Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA
MA Nielsen, VV Pinto, M Resende… - Infection and …, 2009 - Am Soc Microbiol
In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
[HTML][HTML] Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
A Chêne, S Gangnard, C Dechavanne, S Dechavanne… - NPJ vaccines, 2018 - nature.com
Over 50 million women are exposed to the risk of malaria during pregnancy every year.
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
[HTML][HTML] Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under …
Background Pregnancy-associated malaria (PAM) is a serious consequence of the
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …
adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum …