Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants
L Barfod, T Dobrilovic, P Magistrado… - The Journal of …, 2010 - journals.aai.org
Acquired protection from Plasmodium falciparum placental malaria, a major cause of
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …
maternal, fetal, and infant morbidity, is mediated by IgG specific for the P. falciparum …
Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
P Andersen, MA Nielsen, M Resende, TS Rask… - PLoS …, 2008 - journals.plos.org
Pregnancy-associated malaria is caused by Plasmodium falciparum malaria parasites
binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is …
binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is …
The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site
A Babakhanyan, RGF Leke, A Salanti, N Bobbili… - PloS one, 2014 - journals.plos.org
In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA
antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding …
antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding …
Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains
JYA Doritchamou, R Morrison, JP Renn… - Communications …, 2019 - nature.com
Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies
B Bordbar, N Tuikue-Ndam, P Bigey, J Doritchamou… - Vaccine, 2012 - Elsevier
PURPOSE OF THE RESEARCH: VAR2CSA is considered as the main target of protective
immunity against pregnancy-associated malaria. VAR2CSA high molecular weight …
immunity against pregnancy-associated malaria. VAR2CSA high molecular weight …
Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies
JP Semblat, A Raza, SA Kyes, JA Rowe - Molecular and biochemical …, 2006 - Elsevier
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …
infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental …
Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of …
T Saveria, AV Oleinikov, K Wiliamson… - Infection and …, 2013 - Am Soc Microbiol
Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …
chondroitin sulfate A (CSA) and sequester in placental tissue. Variant surface antigen 2-CSA …
Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA
J Bockhorst, F Lu, JH Janes, J Keebler… - Molecular and …, 2007 - Elsevier
VAR2CSA is the main candidate for a pregnancy malaria vaccine, but vaccine development
may be complicated by sequence polymorphism. Here, we obtained partial or full-length …
may be complicated by sequence polymorphism. Here, we obtained partial or full-length …
High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria
VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …
Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA: This article became available OnlineOpen after it …
L Barfod, NL Bernasconi, M Dahlbäck… - Molecular …, 2007 - Wiley Online Library
Pregnancy‐associated malaria (PAM) is caused by Plasmodium falciparum‐infected
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …