[HTML][HTML] The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium …
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
Towards a vaccine against pregnancy-associated malaria
NT Ndam, P Deloron - Parasite, 2008 - parasite-journal.org
The consequences of pregnancy-associated malaria on pregnant women (anaemia), their
babies (birth weight reduction), and infants (increased morbidity and mortality) are well …
babies (birth weight reduction), and infants (increased morbidity and mortality) are well …
[HTML][HTML] Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin
NT Ndam, L Denoeud-Ndam… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …
[HTML][HTML] A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
[HTML][HTML] Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen
Plasmodium falciparum malaria remains one of the world's foremost health problems,
primarily in highly endemic regions such as Sub-Saharan Africa, where it is responsible for …
primarily in highly endemic regions such as Sub-Saharan Africa, where it is responsible for …
High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant
death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before …
death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before …
Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA-Binding Parasites
B Gamain, AR Trimnell, C Scheidig… - The Journal of …, 2005 - academic.oup.com
Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE)
sequestration in the placenta. Recent work suggests that var genes could play an important …
sequestration in the placenta. Recent work suggests that var genes could play an important …
[HTML][HTML] Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict …
M Fried, JD Kurtis, B Swihart, R Morrison, S Pond-Tor… - Malaria Journal, 2018 - Springer
Background Maternal malaria is a tropical scourge associated with poor pregnancy
outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they …
outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they …
[HTML][HTML] Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 …
M Resende, SB Ditlev, MA Nielsen, S Bodevin… - International journal for …, 2009 - Elsevier
Individuals living in areas with high Plasmodium falciparum transmission acquire immunity
to malaria over time and adults have a markedly reduced risk of contracting severe disease …
to malaria over time and adults have a markedly reduced risk of contracting severe disease …