[HTML][HTML] The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium …

MA Nielsen, M Resende, WA de Jongh, SB Ditlev… - PLoS …, 2015 - journals.plos.org
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …

Towards a vaccine against pregnancy-associated malaria

NT Ndam, P Deloron - Parasite, 2008 - parasite-journal.org
The consequences of pregnancy-associated malaria on pregnant women (anaemia), their
babies (birth weight reduction), and infants (increased morbidity and mortality) are well …

[HTML][HTML] Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin

NT Ndam, L Denoeud-Ndam… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …

[HTML][HTML] A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein

U Iyamu, DF Vinals, B Tornyigah, E Arango… - Frontiers in Cellular …, 2023 - frontiersin.org
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …

[HTML][HTML] Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen

E Talundzic, S Shah, O Fawole, S Owino, JM Moore… - PloS one, 2012 - journals.plos.org
Plasmodium falciparum malaria remains one of the world's foremost health problems,
primarily in highly endemic regions such as Sub-Saharan Africa, where it is responsible for …

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

PA Magistrado, D Minja, J Doritchamou, NT Ndam… - Vaccine, 2011 - Elsevier
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant
death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before …

Identification of Multiple Chondroitin Sulfate A (CSA)–Binding Domains in the var2CSA Gene Transcribed in CSA-Binding Parasites

B Gamain, AR Trimnell, C Scheidig… - The Journal of …, 2005 - academic.oup.com
Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE)
sequestration in the placenta. Recent work suggests that var genes could play an important …

[HTML][HTML] Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict …

M Fried, JD Kurtis, B Swihart, R Morrison, S Pond-Tor… - Malaria Journal, 2018 - Springer
Background Maternal malaria is a tropical scourge associated with poor pregnancy
outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they …

[HTML][HTML] Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA

SSR Raghavan, R Dagil, M Lopez-Perez… - PLoS …, 2022 - journals.plos.org
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 …

M Resende, SB Ditlev, MA Nielsen, S Bodevin… - International journal for …, 2009 - Elsevier
Individuals living in areas with high Plasmodium falciparum transmission acquire immunity
to malaria over time and adults have a markedly reduced risk of contracting severe disease …