The evasion of apoptosis, or programmed cell death, is a hallmark of cancer, which
promotes tumor initiation and progression. The evasion is in part attributable to the over …

Many cancer cells maintain survival through over-expression of anti-apoptotic BCL-2 family
proteins, which sequester high levels of their pro-apoptotic counterparts. While this makes …

Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the …

There is an urgent need for new therapeutic agents to treat patients with T-cell lymphoma
(TCL). Multiple hematologic malignancies evade apoptosis through overexpression of anti …

Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis.
Extensively established key effectors of such apoptotic bypass mechanisms, the …

This Patent Highlight focuses on the development of Bcl-xL/Bcl-2 dual inhibitors with
minimized platelet toxicity to improve cancer treatment strategies. Acknowledging the critical …

Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating
programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals …

Apoptosis (or programmed cell death) is a genetically controlled “cell suicide” pathway
which plays an essential role in deleting excess, unwanted or damaged cells during …

Anti-apoptotic protein BCL-X L plays a key role in tumorigenesis and cancer chemotherapy
resistance, rendering it an attractive target for cancer treatment. However, BCL-X L inhibitors …

Abstract B-cell lymphoma-2 (Bcl-2) family proteins are key regulators of apoptosis, which is
vital for proper tissue development and cellular homeostasis. Apoptosis occurs via activation …