Lysosome‐mediated macroautophagy, including lipophagy, is activated under nutrient
deprivation but is repressed after feeding. We show that, unexpectedly, feeding activates …

The fat mass and obesity-associated (FTO) gene is tightly related to body weight and fat
mass, and plays a pivotal role in regulating lipid accumulation in hepatocytes. However, the …

Abstract Fibroblast growth factor 21 (FGF21) is a modulator of energy homeostasis and is
increased in human nonalcoholic liver disease (NAFLD) and after feeding of methionine …

Previous studies have shown that administration of fibroblast growth factor-19 (FGF-19)
reverses diabetes, hepatic steatosis, hyperlipidemia, and adipose accretion in animal …

Nonalcoholic fatty liver disease (NAFLD) is a pathological syndrome characterized by
excessive fat deposition in hepatocytes. A sedentary lifestyle is a major risk factor for …

Background and Purpose Because of the absence of effective therapies for metabolic
dysfunction‐associated steatohepatitis (MASH), there is a rising interest in fibroblast growth …

Background Fibroblast growth factor 21 (FGF21) is expressed in several metabolically active
tissues, including liver, fat, and acinar pancreas, and has pleiotropic effects on metabolic …

The orphan nuclear receptor small heterodimer partner (SHP) regulates metabolic pathways
involved in hepatic bile acid production and both lipid and glucose homeostasis via the …

Critical regulation of bile acid (BA) pool size and composition occurs via an intensive
molecular crosstalk between the liver and gut, orchestrated by the combined actions of the …

To investigate the role of bile acids (BAs) in the pathogenesis of diet-induced nonalcoholic
steatohepatitis (NASH), we fed a “Western-style diet”[high fructose, high fat (HFF)] enriched …