Discovery and characterization of inhibitors of human palmitoyl acyltransferases
CE Ducker, LK Griffel, RA Smith, SN Keller… - Molecular cancer …, 2006 - AACR
The covalent attachment of palmitate to specific proteins by the action of palmitoyl
acyltransferases (PAT) plays critical roles in the biological activities of several oncoproteins …
acyltransferases (PAT) plays critical roles in the biological activities of several oncoproteins …
DHHC20: a human palmitoyl acyltransferase that causes cellular transformation
JM Draper, CD Smith - Molecular membrane biology, 2010 - Taylor & Francis
Palmitoylation is required for the activities of several cancer-associated proteins, making the
palmitoyl acyltransferase (PAT) enzymes that catalyze these reactions potential targets for …
palmitoyl acyltransferase (PAT) enzymes that catalyze these reactions potential targets for …
Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase
CE Ducker, EM Stettler, KJ French, JJ Upson, CD Smith - Oncogene, 2004 - nature.com
Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug
design due to their pivotal roles in the subcellular localization of a number of oncogenes. We …
design due to their pivotal roles in the subcellular localization of a number of oncogenes. We …
Palmitoyl acyltransferase assays and inhibitors
JM Draper, CD Smith - Molecular membrane biology, 2009 - Taylor & Francis
Palmitoylated proteins have been implicated in several disease states including
Huntington's, cardiovascular, T-cell mediated immune diseases, and cancer. To proceed …
Huntington's, cardiovascular, T-cell mediated immune diseases, and cancer. To proceed …
Protein palmitoylation in cancer: molecular functions and therapeutic potential
B Zhou, Q Hao, Y Liang, E Kong - Molecular oncology, 2023 - Wiley Online Library
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …
Palmitoylation of proteins in cancer
MD Resh - Biochemical Society transactions, 2017 - portlandpress.com
Post-translational modification of proteins by attachment of palmitate serves as a mechanism
to regulate protein localization and function in both normal and malignant cells. Given the …
to regulate protein localization and function in both normal and malignant cells. Given the …
Identification of protein palmitoylation inhibitors from a scaffold ranking library
The addition of palmitoyl moieties to proteins regulates their membrane targeting,
subcellular localization, and stability. Dysregulation of the enzymes which catalyzed the …
subcellular localization, and stability. Dysregulation of the enzymes which catalyzed the …
Sensitive and rapid analysis of protein palmitoylation with a synthetic cell-permeable mimic of SRC oncoproteins
SP Creaser, BR Peterson - Journal of the American Chemical …, 2002 - ACS Publications
The localization of oncogenic Src and Ras proteins to cellular plasma membranes is critical
for the proliferation of specific cancers. In addition to other lipid modifications, these proteins …
for the proliferation of specific cancers. In addition to other lipid modifications, these proteins …
Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method
Protein palmitoylation is the post-translational addition of the 16-carbon fatty acid palmitate
to specific cysteine residues by a labile thioester linkage. Palmitoylation is mediated by a …
to specific cysteine residues by a labile thioester linkage. Palmitoylation is mediated by a …
A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity
AS Varner, ML De Vos, SP Creaser, BR Peterson… - Analytical …, 2002 - Elsevier
Although protein palmitoylation is essential for targeting many important signaling proteins
to the plasma membrane, the mechanism by which palmitoylation occurs is uncharacterized …
to the plasma membrane, the mechanism by which palmitoylation occurs is uncharacterized …