In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain,
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …

In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …

The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by
neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction …

Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a
component of some degenerative neurological disorders such as Alzheimer's disease (AD) …

Excitatory and inhibitory balance of neuronal network activity is essential for normal brain
function and may be of particular importance to memory. Apolipoprotein (apo) E4 and …

Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …

Integrative gene network approaches enable new avenues of exploration that implicate
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …

High levels of the amyloid-beta (Aβ) peptide have been shown to disrupt neuronal function
and induce hyperexcitability, but it is unclear what effects Aβ-associated hyperexcitability …

Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …

Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …