Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease
In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain,
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …
Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
T Kudo, H Takuwa, M Takahashi, T Urushihata… - Iscience, 2023 - cell.com
In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …
with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought …
Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer's disease
LT Zhou, D Liu, HC Kang, L Lu, HZ Huang, WQ Ai… - Science …, 2023 - science.org
The neuron-glia cross-talk is critical to brain homeostasis and is particularly affected by
neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction …
neurodegenerative diseases. How neurons manipulate the neuron-astrocyte interaction …
Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy
JK Holth, VC Bomben, JG Reed, T Inoue… - Journal of …, 2013 - Soc Neuroscience
Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a
component of some degenerative neurological disorders such as Alzheimer's disease (AD) …
component of some degenerative neurological disorders such as Alzheimer's disease (AD) …
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation
LM Tong, B Djukic, C Arnold, AK Gillespie… - Journal of …, 2014 - Soc Neuroscience
Excitatory and inhibitory balance of neuronal network activity is essential for normal brain
function and may be of particular importance to memory. Apolipoprotein (apo) E4 and …
function and may be of particular importance to memory. Apolipoprotein (apo) E4 and …
Early-onset network hyperexcitability in presymptomatic Alzheimer's disease transgenic mice is suppressed by passive immunization with anti-human APP/Aβ …
Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement …
Integrative gene network approaches enable new avenues of exploration that implicate
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus
High levels of the amyloid-beta (Aβ) peptide have been shown to disrupt neuronal function
and induce hyperexcitability, but it is unclear what effects Aβ-associated hyperexcitability …
and induce hyperexcitability, but it is unclear what effects Aβ-associated hyperexcitability …
Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice
P Sompol, JL Furman, MM Pleiss… - Journal of …, 2017 - Soc Neuroscience
Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
[HTML][HTML] Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …