Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …

Atherosclerosis causing heart attack and stroke is the leading cause of death in the modern
world. Therapy for end-stage atherosclerotic disease using CD34+ hematopoietic cells has …

As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a
chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD …

Monocytosis and neutrophilia are frequent events in atherosclerosis. These phenomena
arise from the increased proliferation of hematopoietic stem and multipotential progenitor …

Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …

Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …

Rationale Hematopoietic stem/progenitor cells (HSPC) are responsible for maintaining the
blood system as a result of their self-renewal and multilineage differentiation capacity …

Aim Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only
drives atherosclerosis by directing the innate immune response at plaque level but also …

The major event initiating atherosclerosis is hypercholesterolemia-induced disruption of
vascular endothelium integrity. In settings of endothelial damage, endothelial progenitor …

Murphy and Tall Local Macrophage Proliferation in Atherosclerosis 237 not continue
indefinitely and that the macrophage pool of established lesions is ultimately derived from a …