Memory CD8 T cells confer increased protection to immune hosts upon secondary viral,
bacterial, and parasitic infections. The level of protection provided depends on the numbers …

Inflammatory cytokines induced by infection or vaccination with adjuvant act directly or
indirectly on CD8 T cells to modulate their expansion, contraction, and acquisition of …

Historically, most immune response studies have been limited to analyses of lymphoid
tissue. However, peripheral sites of infection are likely to represent important sites of cell …

Mucosal antigen-specific CD4 T-cell responses to intestinal pathogens remain incompletely
understood. Here we examined the CD4 T-cell response after oral infection with an …

Viral infections have been shown to induce lymphopenias that lower memory CD8 T cell
frequencies, and they also have been shown to cause a permanent loss of memory cells …

IFN-γ is critical for innate immunity against Listeria monocytogenes (L. monocytogenes), and
it has long been thought that NK cells are the major source of IFN-γ during the first few days …

During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply
an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells …

CD8+ T cell responses to viral infection are characterized by the emergence of dominant
and subdominant CTL populations. The immunodominance hierarchies of these populations …

Memory CD8 T cells can be activated and induced to produce cytokines and increase stores
of cytolytic proteins not only in response to cognate antigen (Ag) but also in response to …

Glycolysis facilitates the rapid recall response of CD8+ memory T (Tm) cells. However, it
remains unclear whether Tm cells uptake exogenous glucose or mobilize endogenous …