Background Idiopathic interstitial pneumonia, typified by idiopathic pulmonary fibrosis (IPF),
causes acute exacerbation in about 40% of Japanese patients in the clinical course. Acute …

Background Mucus overproduction is a characteristic of inflammatory pulmonary diseases
including asthma, chronic bronchitis, and cystic fibrosis. Expression of two mucin genes …

RATIONALE: We have discovered that a common MUC5B promoter variant (rs35705950) is
the strongest risk factor for the development of idiopathic pulmonary fibrosis (IPF). We …

Although the pathogenesis of idiopathic pulmonary fibrosis (IPF) remains elusive (1), one of
the most intriguing aspects concerns the possible role of mucins. A strong association has …

Mucus hypersecretion in airways is a common pathological change observed in chronic
inflammatory diseases and asthma. We investigated the new role of cell attachment to the …

Background: Excessive mucin secretion in the airway is an important feature of airway
inflammatory diseases. MUC5AC expression is regulated by a variety of stimuli such as …

Dysregulation of gel-forming mucins is associated with many airway diseases. Better
knowledge of the pathophysiological mechanisms linking mucins and respiratory diseases …

The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis
(IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined …

MUC1 is a membrane-tethered mucin expressed on the surface of epithelial cells lining
mucosal surfaces. Recent studies have begun to elucidate the physiologic function of MUC1 …

MUC1 (MUC in human; Muc in animals) is a transmembrane mucin glycoprotein expressed
in mucosal epithelial cells and hematopoietic cells. MUC1 is involved in the resolution of …