MUC5B is the principal secreted airway mucin, present in airway mucus at a concentration
z10-fold higher than the other secreted airway mucin, MUC5AC (1, 2). The report in 2011 …

Mucus overproduction is an important feature of bronchial asthma. MUC5AC mucin is a
major component of mucus and is overproduced in patients with asthma. Although …

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies …

Muc1 is a heterodimeric mucin that is expressed on the apical surface of airway epithelial
cells as well as hematopoietic cells. Both in vivo and in vitro studies revealed that Muc1 …

Airway surface fluid contains two layers of mucins consisting mainly of 5 different mucin
gene products. While the outer layer contains two gel-forming mucins (MUC5AC and …

INTRODUCTION: MUC5B small airways/mucins in the pathogenesis of pulmonary fibrosis.
Our aim was to compare the expression of MUC5B and MUC5AC, the two main airway …

Background: Increased secretion of mucus is a hallmark of many respiratory diseases and
contributes significantly to the airflow limitation experienced by many patients. While the …

Rationale Smoking-related chronic obstructive pulmonary disease (COPD) is associated
with dysregulated production of mucus. Mucins (MUC) are important both for mucus …

Background Mucin 1 (MUC1) is a membrane tethered protein on airway epithelial cells. This
protein is upregulated and plays an important anti-inflammatory role during acute lung …

Evolution represents genomic adaptions to dynamic environmental challenges, and these
genomic changes often come with both beneficial and detrimental consequences. Genomic …