Purpose Inotropes and vasopressors are cornerstone of therapy in septic shock, but search
for the best agent is ongoing. We aimed to determine which vasoactive drug is associated …

Vasopressin is a potent vasopressor for improving organ perfusion during septic shock. The
rationale for the use of vasopressin is its relative deficiency of plasma levels and …

Severe sepsis and septic shock are medical emergencies affecting almost 230,000
Americans every year with almost 40,000 deaths with an estimated cost of almost 25 billion …

When fluid administration fails to restore an adequate arterial pressure and organ perfusion
in patients with septic shock, therapy with vasopressor agents should be initiated. The …

Adrenergic and non‐adrenergic vasopressor agents can be used to correct hypotension in
shock states. For a similar increase in arterial pressure, these agents may be associated …

Cardiovascular failure is one of the central therapeutic problems in patients with severe
infection. Although norepinephrine is a potent and, in most cases, highly effective …

Rationale: Norepinephrine is a first-line agent for the treatment of hypotension in septic
shock. However, its frequency of use and potential barriers to its use are unclear. Objectives …

Purpose We performed an individual patient data meta-analysis to investigate the possible
benefits and harms of vasopressin therapy in adults with septic shock both overall and in pre …

Background: Vasopressor plays a crucial role in septic shock. However, the time for
vasopressor initiation remains controversial. We conducted a systematic review and meta …

Background: There is little data guiding clinicians on how to discontinue vasopressors
among septic shock patients on concomitant norepinephrine (NE) and vasopressin (VP) …