It has been known for many years that a latent period exists between the administration of a
carcinogen to an organism and the actual appearance of pathologically or clinically …

An understanding of the mechanisms and characteristics of the natural history of neoplastic
development during carcinogenesis in lower mammals is essential to the ultimate control of …

The sequence of possible cellular, tissue, biochemical, and molecular changes that are
important during the development of experimental liver cancer with chemicals is reviewed …

I. Introduction"... on peut retrouver dans ce processus comme une sorte de sblection
pathologique qui amrne la Abbreviations: AAF, 2-acetylaminofluorene; ATPase, adenosine …

In a pioneering study on experimental hepatocarcinogenesis, Sasaki and Yoshida [1]
detailed the step by step changes of the liver parenchyma leading to the development of …

Critical parameters in the quantitation of altered hepatic foci (AHF) developing during
multistage hepatocarcinogenesis in the rat include: 1) the enumeration of AHF induced by …

Liver cell cancer can be induced in animals by a diverse group of chemicals. The majority of
these require metabolic conversion to a reactive derivative in order to initiate …

Differences in the distribution of phenotypic alterations in initiated and promoted cell
populations reflect both the dose and the action of the specific initiating agent, as well as the …

Publisher Summary The investigation of nutritional and other environmentally derived
influences in animal experiments has established that vast arrays of compounds are …

Experiments were designed to determine the role of cell proliferation in the initiation of liver
carcinogenesis induced by chemicals. To investigate this, two methylating carcinogens, N …