Objective: To evaluate the effect of hydroxysafflor yellow A (HSYA) on thioacetamide-
induced liver fibrosis. Methods: Thioacetamide was administered to rats intraperitoneally in …

Hepatic fibrosis is a reversible pathological process, in which fibrotic tissue is excessively
deposited in the liver during the repair process that follows hepatic injury. Early prevention …

A key feature in the molecular pathogenesis of liver fibrosis requires maintenance of the
activated hepatic stellate cells (HSCs) phenotype by inhibition of apoptosis. The induction of …

Objective: To investigate the antifibrotic effects of Chrysanthemum indicum ethanol extract
(CIEE) against activated hepatic stellate cells (HSC) and thioacetamide (TAA)-induced …

Abstract Context: Allium senescens Linn.(Liliaceae)(ASL) has been traditionally used in
Korea and other Asian countries for improving digestive and liver functions. Objective: The …

Objective: To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods: The …

Objective To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods The …

Hydroxysafflor yellow A (HSYA) was isolated from the dried flower of Carthamus tinctorius L.
which was extensively used in traditional Chinese medicine to treat cirrhosis. However, the …

Context: One approach to protect against liver fibrosis is the use of herb-derived natural
compounds, such as hydroxysafflor yellow A (HSYA). The antifibrosis effect of HYSA against …

Hepatic stellate cells (HSCs) undergo activation during the development of liver fibrosis.
Transcription factor myocyte enhancer factor (MEF2) 2C plays a key role in this process. In …