Tuberculosis (TB), an airborne pulmonary disease caused by Mycobacterium tuberculosis
(M. tb), poses an unprecedented health and economic burden to most of the developing …

In 2001, the WHO declared TB a global emergency, as one third of the worlds population
suffered from latent M. tuberculosis infection. Today, a decade later, millions of people still …

Clinical trials are sometimes classified as being explanatory or pragmatic, although they are
rarely reported in that way. Explanatory trials may seek to investigate the efficacy of new …

Background Improvement in tuberculosis treatment regimens requires selection of
antibiotics and dosing schedules from a large design space of possibilities. Incomplete …

Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB
reduces mortality dramatically and should maximize cure, preventing ongoing transmission …

Tuberculosis (TB) remains an infectious disease of global significance and a leading cause
of death in low-and middle-income countries. Significant effort has been directed towards …

Abstract 25 years after the declaration of a Global Emergency by the World Health
Organization, tuberculosis (TB) remains a major enemy to the humankind. During this …

Highlights•Genomic and transcriptional analyses have paved the way to study
Mycobacterium tuberculosis (Mtb) at a molecular level.•Shotgun-MS, S/MRM and …

World TB Day commemorates Dr Robert Koch's first announcement on March 24, 1882, that
the bacterium Mycobacterium tuberculosis is the causative agent of tuberculosis. Currently …

Objectives The handbook's ultimate objective is to help ensure that local, national and
institutional TB control programmes are efficiently organized and effective in decreasing the …