The non-peptidergic opioid receptor-like 1 (ORL1, OP4) receptor ligand, Ro 64-6198 {(1S,
3aS)-8-(2, 3, 3a, 4, 5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1, 3, 8-triaza-spiro [4, 5] …

We have previously reported the chemistry and antinociceptive properties of a series of
glycosylated enkephalin analogs (glycopeptides) exhibiting approximately equal affinity and …

Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like
receptor, LC132. Initial reports suggested that OFQ increased pain sensitivity when injected …

Morphine and related opioid agonists are frequently used in dogs for their analgesic
properties, their sedative effects and as adjuncts to anesthesia. Such compounds may be …

The orvinols, including buprenorphine, emerged from research carried out by Reckitt and
Colman in the 1960s and 1970s. Regulatory approval of buprenorphine for the treatment of …

Given that μ opioid (MOP) and canabinoid (CB1) receptors are colocalized in various
regions of the central nervous system and have been reported to associate as heteromer …

G protein-biased mu opioid receptor (GPB-MOR) agonists constitute an emerging class of
opioid analgesics. The first-in-class GPB-MOR agonist TRV130 (oliceridine) produces …

Abstract Opioid Use Disorder (OUD) can be described as intense preoccupation with using
or obtaining opioids despite the negative consequences associated with their use. As the …

Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-
terminal splice variants. However, their behavioral relevance remains unknown. The present …

An experimental medicine comparison of the novel biased ligand TRV130 to morphine
reveals that selective signaling at the mu opioid receptor may improve opioid therapeutic …