The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases
É Toussirot - Inflammation & Allergy-Drug Targets (Formerly …, 2012 - ingentaconnect.com
IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential
for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic …
for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic …
IL-17 in the pathogenesis of disease: good intentions gone awry
S Majumder, MJ McGeachy - Annual review of immunology, 2021 - annualreviews.org
The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …
through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include …
Interleukin 17A: toward a new understanding of psoriasis pathogenesis
Molecular and cellular understanding of psoriasis pathogenesis has evolved considerably
over the last 30 years beginning in the early 1980s when psoriasis was thought to be a skin …
over the last 30 years beginning in the early 1980s when psoriasis was thought to be a skin …
Decoding IL-23 signaling cascade for new therapeutic opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro - Cells, 2020 - mdpi.com
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
Therapeutic potential of targeting IL-17
Therapeutic potential of targeting IL-17 | Nature Immunology Skip to main content Thank you for
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New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers
IT Chyuan, JH Lai - Biochemical pharmacology, 2020 - Elsevier
Abstract The cytokines interleukin-12 (IL-12) and IL-23 share a common IL-12/IL-23p40
subunit in structure and play a central role in T cell-mediated responses in inflammation …
subunit in structure and play a central role in T cell-mediated responses in inflammation …
The role of IL 23 in the treatment of psoriasis
L Puig - Expert review of clinical immunology, 2017 - Taylor & Francis
ABSTRACT Introduction: The IL-23/IL-17 axis is currently considered to be crucial in the
pathogenesis of psoriasis. Human IL-23 is primarily produced by antigen-presenting cells …
pathogenesis of psoriasis. Human IL-23 is primarily produced by antigen-presenting cells …
Interleukin-17 in rheumatoid arthritis: Trials and tribulations
LS Taams - Journal of Experimental Medicine, 2020 - rupress.org
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine with well-characterized biological
effects on stromal cell activation, angiogenesis, and osteoclastogenesis. The presence of …
effects on stromal cell activation, angiogenesis, and osteoclastogenesis. The presence of …
Interleukin-22: a likely target for treatment of autoimmune diseases
X Yang, SG Zheng - Autoimmunity reviews, 2014 - Elsevier
Abstract Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by
many different types of lymphocytes including both those of the innate and adaptive immune …
many different types of lymphocytes including both those of the innate and adaptive immune …