IL-23 is a member of the IL-12 cytokine family that drives a highly pathogenic T cell
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …

Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …

Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

Chronic inflammatory diseases like psoriasis, Crohn's disease (CD), multiple sclerosis (MS),
rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where …

Interleukin (IL) 23 is a heterodimeric cytokine composed of a p19 subunit and the p40
subunit of IL-12. IL-23 affects memory T cell and inflammatory macrophage function through …

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized
by autoantibodies production and immune complex deposition with systemic clinical …

Summary Interleukin-12 and interleukin-23 have distinct roles in mediating host defense and
autoimmune inflammation. Although targeting interleukin-12 and interleukin-23 …

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial
roles in host defence against microbial organisms and the development of inflammatory …

Psoriasis is a common chronic inflammatory skin disease, associated with substantial
comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived …

The term spondyloarthritis (SpA) is used to describe a group of inflammatory autoimmune
diseases, including ankylosing spondylitis and psoriatic arthritis, with common genetic risk …