Background Dysregulation of the epigenome is a common event in malignancy; however,
deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …

Aberrant DNA methylation is an early event in breast carcinogenesis and plays a critical role
in regulating gene expression. Here, we perform genome-wide expression-methylation …

Epigenetic gene regulation has influence over a diverse range of cellular functions,
including the maintenance of pluripotency, differentiation, and cellular identity, and is …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

The timing and progression of DNA methylation changes during carcinogenesis are not
completely understood. To develop a timeline of aberrant DNA methylation events during …

Introduction Epigenetic modifications such as aberrant DNA methylation has long been
associated with tumorogenesis. Little is known, however, about how these modifications …

Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic
alterations during tumorigenesis including aberrant DNA hypermethylation of tumor …

Breast cancer, one of the most common and deadliest malignancies in developed countries,
is a remarkably heterogeneous disease, which is clinically reflected by patients who display …