There is cumulative evidence that the serine-threonine kinase Akt and its downstream
nuclear transcription factor CREB are involved in neuronal survival and protection. The Akt …

Background: Nobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit
cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and …

Background Post-ischemic oxidative stress and inflammation play pivotal roles in the
pathogenesis of ischemic stroke and may represent therapeutic targets. Nobiletin (NOB) has …

Nobiletin, a citrus polymethoxylated flavone, is reported to possess various pharmacological
activities such as anticancer, anti-inflammation, and antioxidant effects. Recently, nobiletin …

Background Oxidative damage plays a pivotal role in the pathogenesis of cerebral ischemic
stroke and may represent a target for treatment. Our previous studies have proved that …

Decreased cerebral blood flow causes cognitive impairments and neuronal injury in the
progressive age-related neurodegenerative disorders such as Alzheimer's disease (AD) and …

Nobiletin (NOB) possesses multiple pharmacological effects, but its anti-apoptotic property
has acquired a great deal of attention. Endoplasmic reticulum (ER) stress (ERS)-induced …

Biochanin A, an O-methylated natural isoflavonoid classified as phytoestrogen, has been
reported to show anti-tumorigenesis, anti-oxidation, and anti-inflammatory properties …

Background Stroke is regarded as one of the main health concerns globally, presenting with
high mortality and morbidity rates. Cerebral ischemic damage and infarction are critically …

Increasing evidence indicates that nobiletin (NOB) is a promising neuroprotective agent.
Astrocyte activation plays a key role in neurodegenerative disorders. Thus, this study aims to …