Hexafluoroisopropanol mediated benign synthesis of 2 H-pyrido [1, 2-a] pyrimidin-2-ones by using a domino protocol

Z Alsharif, MA Ali, H Alkhattabi, D Jones… - New Journal of …, 2017 - pubs.rsc.org
A domino strategy has been used for the synthesis of 2H-pyrido [1, 2-a] pyrimidin-2-ones.
Four sequential reactions: aza-Michael addition, water elimination, intramolecular acyl …

Hexafluoroisopropyl alcohol mediated synthesis of 2, 3-dihydro-4H-pyrido [1, 2-a] pyrimidin-4-ones

MA Alam, Z Alsharif, H Alkhattabi, D Jones… - Scientific Reports, 2016 - nature.com
An efficient synthesis of novel 2, 3-dihydro-4H-pyrido [1, 2-a] pyrimidin-4-ones has been
reported. Inexpensive and readily available substrates, environmentally benign reaction …

Unexpected Synthesis of 5,6-Dihydropyridin-2(1H)-ones by a Domino Ugi/Aldol/Hydrolysis Reaction Starting from Baylis–Hillman Phosphonium Salts

XH Zeng, HM Wang, MW Ding - Organic letters, 2015 - ACS Publications
Unexpected Synthesis of 5,6-Dihydropyridin-2(1H)-ones by a Domino Ugi/Aldol/Hydrolysis
Reaction Starting from Baylis–Hillman Phosphonium Salts | Organic Letters ACS ACS …

One‐pot synthesis of 3, 4‐dihydropyridin‐2‐ones via tandem reaction of Blaise reaction intermediate and acrylic ester

T Meng, L Liu, H Jia, L Ren, C Feng… - Applied …, 2016 - Wiley Online Library
An efficient method for the synthesis 3, 4‐dihydropyridin‐2‐ones has been developed via
tandem one‐pot Michael‐type addition and cyclization of the Blaise reaction intermediate …

Synthesis of 3,4-Dihydropyridin-2(1H)-ones and 3,4-Dihydro-2H-pyrans via Four-Component Reactions of Aromatic Aldehydes, Cyclic 1,3-Carbonyls, Arylamines …

J Sun, EY Xia, Q Wu, CG Yan - ACS Combinatorial Science, 2011 - ACS Publications
A protocol has been developed for the efficient synthesis of structurally diverse 3, 4-
dihydropyridin-2 (1 H)-ones and 3, 4-dihydro-2 H-pyrans via four-component reactions of …

Convenient one-pot four-component synthesis of 6, 8-disubstituted-5, 6, 7, 8-tetrahydropyrimido [4, 5-d] pyrimidin-4 (3H)-ones via a triple Mannich Reaction

AFM EL-Mahdy, HAH El-Sherief… - Australian Journal of …, 2019 - CSIRO Publishing
An efficient and simple one-pot four-component protocol has been developed and
performed for the synthesis of 6, 8-disubstituted-5, 6, 7, 8-tetrahydropyrimido [4, 5-d] …

An expedient and divergent tandem one-pot synthesis of pyrimidin-2, 4-diones using the blaise reaction intermediate

YS Chun, Z Xuan, JH Kim, S Lee - Organic letters, 2013 - ACS Publications
A novel divergent tandem one-pot method for the synthesis of 3, 5, 6-trisubstituted 1 H-
pyrimidin-2, 4-dione derivatives is developed. In the presence of 10 mol% of Cu (OAc) 2, the …

Synthesis of polysubstituted 1, 4-dihydropyridines via three-component reaction

S Balalaie, L Baoosi, F Tahoori, F Rominger… - Tetrahedron, 2013 - Elsevier
An efficient one-pot synthesis of novel N-substituted 1, 4-dihydropyridine derivatives via a
three-component reaction of primary amines, dialkyl acetylenedicarboxylates, and methyl …

Aqueous Synthesis of 3, 4‐Dihydropyridinones from Acryloyl Chloride and Enaminones by Domino Amidation and Intramolecular Michael Addition

T Luo, H Xu, Y Liu - ChemistrySelect, 2019 - Wiley Online Library
A facile method for the synthesis of 3, 4‐dihydropyridin‐2 (1H)‐ones (3, 4‐
dihydropyridinones) has been developed via the reactions of acryloyl chloride and …

PEG1000-Based Dicationic Acidic Ionic Liquid Catalyzed One-pot Synthesis of 1,4-Dihydropyridines via the Hantzsch Reaction

YM Ren, JJ Shao, ZC Wu, MD Xu - Organic Preparations and …, 2014 - Taylor & Francis
Devising reactions that achieve multiple-bond formation in one operation has become one
of the major challenges in the search for efficient syntheses. Multi-component reactions …