Fluoride (F) can induce changes in the expression of several liver proteins. It is suggested
that these changes are dose-and time-dependent. The objective of this study was to analyze …

Fluoride (F) is a potent anti-cariogenic element, but when ingestion is excessive, systemic
toxicity may be observed. This can occur as acute or chronic responses, depending on both …

The mechanisms involved in changes in energy metabolism caused by excessive exposure
to fluoride (F) are not completely understood. The present study employed proteomic tools to …

Background High fluoride levels in drinking water in relation to the prevalence of chronic
kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an …

Fluoride compounds are abundant and widely distributed in the environment at a variety of
concentrations. Further, fluoride induces toxic effects in target organs such as the liver. In …

Studies focusing on possible genotoxic effects of excess fluoride are contradictory and
inconclusive. Currently, studies have reported a probable link to oxidative stress, DNA …

Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …

The mechanism underlying the toxicity of fluoride still remains unknown. To investigate the
effects of different doses of fluoride on blood and tissue oxidative stress and apoptosis, we …

Fluoride induced hepatotoxicity has been extensively studied in both humans and animals.
However, the mechanism underlying in the hepatotoxicity of experimental fluorosis remains …

Chronic fluorosis can severely damage many systems of human body, but its pathogenesis
is unclear. Normal composition and structure of cellular membrane lipids are a basic factor …