Ontologically distinct populations of macrophages differentially contribute to organ fibrosis
through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte …

Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
the histopathological pattern of usual interstitial pneumonia and is associated with a high …

Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the
etiology remains poorly understood. This disease can be lethal and currently has no specific …

Pulmonary fibrosis (PF) is a disease in which excessive extracellular matrix (ECM)
accumulation occurs in the lungs, which induces thickening of the alveolar walls, ultimately …

Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …

A comprehensive understanding of the changes in gene expression in cell types involved in
idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of …

There are currently few treatment options for pulmonary fibrosis. Innovations may come from
a better understanding of the cellular origin of the characteristic fibrotic lesions. We have …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …