VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
R Kivelä, M Bry, MR Robciuc, M Räsänen… - EMBO molecular …, 2014 - embopress.org
Angiogenic growth factors have recently been linked to tissue metabolism. We have used
genetic gain‐and loss‐of function models to elucidate the effects and mechanisms of action …
genetic gain‐and loss‐of function models to elucidate the effects and mechanisms of action …
Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From …
D Bellomo, JP Headrick, GU Silins… - Circulation …, 2000 - Am Heart Assoc
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of
blood vessel growth during development and disease and a strong candidate for angiogenic …
blood vessel growth during development and disease and a strong candidate for angiogenic …
Cardiomyocyte VEGFR‐1 activation by VEGF‐B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction
L Zentilin, U Puligadda, V Lionetti… - The FASEB …, 2010 - Wiley Online Library
Mounting evidence indicates that the function of members of the vascular endothelial growth
factor (VEGF) family extends beyond blood vessel formation. Here, we show that the …
factor (VEGF) family extends beyond blood vessel formation. Here, we show that the …
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
X Li, M Tjwa, I Van Hove, B Enholm… - … , and vascular biology, 2008 - Am Heart Assoc
Objective—The endogenous role of the VEGF family member vascular endothelial growth
factor-B (VEGF-B) in pathological angiogenesis remains unclear. Methods and Results—We …
factor-B (VEGF-B) in pathological angiogenesis remains unclear. Methods and Results—We …
VEGF-B promotes endocardium-derived coronary vessel development and cardiac regeneration
M Räsänen, I Sultan, J Paech, KA Hemanthakumar… - Circulation, 2021 - Am Heart Assoc
Background: Recent discoveries have indicated that, in the developing heart, sinus venosus
and endocardium provide major sources of endothelium for coronary vessel growth that …
and endocardium provide major sources of endothelium for coronary vessel growth that …
[HTML][HTML] The role of the VEGF family in coronary heart disease
Y Zhou, X Zhu, H Cui, J Shi, G Yuan, S Shi… - Frontiers in …, 2021 - frontiersin.org
The vascular endothelial growth factor (VEGF) family, the regulator of blood and lymphatic
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …
vessels, is mostly investigated in the tumor and ophthalmic field. However, the functions it …
VEGF-B taken to our hearts: specific effect of VEGF-B in myocardial ischemia
L Claesson-Welsh - Arteriosclerosis, thrombosis, and vascular …, 2008 - Am Heart Assoc
Vascular endothelial growth factor-B (VEGF-B, see Olofsson et al1) is one of 5 mammalian
VEGF family members, the others being VEGF-A, VEGF-C, VEGF-D, and placental growth …
VEGF family members, the others being VEGF-A, VEGF-C, VEGF-D, and placental growth …
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
T Karpanen, M Bry, HM Ollila… - Circulation …, 2008 - Am Heart Assoc
Vascular endothelial growth factor (VEGF)-B is poorly angiogenic but prominently expressed
in metabolically highly active tissues, including the heart. We produced mice expressing a …
in metabolically highly active tissues, including the heart. We produced mice expressing a …
Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
MH Dijkstra, E Pirinen, J Huusko, R Kivelä… - Scientific reports, 2014 - nature.com
Vascular endothelial growth factor-B (VEGF-B) has been implicated to play a significant role
in coronary vessel growth and endothelial uptake and transport of fatty acids in heart and …
in coronary vessel growth and endothelial uptake and transport of fatty acids in heart and …
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
M Bry, R Kivelä, T Holopainen, A Anisimov… - Circulation, 2010 - Am Heart Assoc
Background—Vascular endothelial growth factor-B (VEGF-B) binds to VEGF receptor-1 and
neuropilin-1 and is abundantly expressed in the heart, skeletal muscle, and brown fat. The …
neuropilin-1 and is abundantly expressed in the heart, skeletal muscle, and brown fat. The …