Comparison of vasodilatory properties of 14, 15-EET analogs: structural requirements for dilation
JR Falck, UM Krishna, YK Reddy… - American Journal …, 2003 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) are endothelium-derived eicosanoids that activate
potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 …
potassium channels, hyperpolarize the membrane, and cause relaxation. We tested 19 …
14,15-Epoxyeicosa-5(Z)-enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in …
KM Gauthier, C Deeter, UM Krishna, YK Reddy… - Circulation …, 2002 - Am Heart Assoc
Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are
mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates …
mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates …
Characterization of 14, 15-epoxyeicosatrienoyl-sulfonamides as 14, 15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding
W Yang, BB Holmes, VR Gopal, RVK Kishore… - … of Pharmacology and …, 2007 - ASPET
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of
arachidonic acid. EETs mediate numerous biological functions. In coronary arteries, they …
arachidonic acid. EETs mediate numerous biological functions. In coronary arteries, they …
20-125Iodo-14, 15-epoxyeicosa-5 (Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site
Y Chen, JR Falck, VR Tuniki, WB Campbell - Journal of Pharmacology and …, 2009 - ASPET
Epoxyeicosatrienoic acids (EETs) are endothelium-derived metabolites of arachidonic acid.
They relax vascular smooth muscle by membrane hyperpolarization. These actions are …
They relax vascular smooth muscle by membrane hyperpolarization. These actions are …
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: Photoaffinity Labeling of a 14,15-Epoxyeicosatrienoic Acid Receptor
Y Chen, JR Falck, VL Manthati, JL Jat… - Biochemistry, 2011 - ACS Publications
Endothelium-derived epoxyeicosatrienoic acids (EETs) relax vascular smooth muscle by
activating potassium channels and causing membrane hyperpolarization. Recent evidence …
activating potassium channels and causing membrane hyperpolarization. Recent evidence …
Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation
CL Oltman, NL Weintraub, M VanRollins… - Circulation …, 1998 - Am Heart Assoc
Cytochrome P450 epoxygenases convert arachidonic acid into 4 epoxyeicosatrienoic acid
(EET) regioisomers, which were recently identified as endothelium-derived hyperpolarizing …
(EET) regioisomers, which were recently identified as endothelium-derived hyperpolarizing …
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids
NL Weintraub, X Fang, TL Kaduce… - Circulation …, 1997 - Am Heart Assoc
Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from
cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) …
cytochrome P-450 metabolism of arachidonic acid. EETs and their diol products (DHETs) …
Stable 5, 6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation
W Yang, KM Gauthier, LM Reddy, B Sangras… - …, 2005 - Am Heart Assoc
5, 6-Epoxyeicosatrienoic acid (5, 6-EET) is a cytochrome P450 epoxygenase metabolite of
arachidonic acid that causes vasorelaxation. However, investigations of its role in biological …
arachidonic acid that causes vasorelaxation. However, investigations of its role in biological …
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14, 15-epoxyeicosa-8 (Z)-enoic acid
W Yang, VR Tuniki, S Anjaiah, JR Falck… - … of Pharmacology and …, 2008 - ASPET
Epoxyeicosatrienoic acids (EETs) are important regulators of vascular tone and
homeostasis. Whether they initiate signaling through membrane receptors is unclear. We …
homeostasis. Whether they initiate signaling through membrane receptors is unclear. We …
14, 15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries
KM Gauthier, JR Falck, LM Reddy… - Pharmacological …, 2004 - Elsevier
Arachidonic acid metabolites contribute to the regulation of vascular tone and therefore
tissue blood flow. The vascular endothelium metabolizes arachidonic acid by cytochrome …
tissue blood flow. The vascular endothelium metabolizes arachidonic acid by cytochrome …