Zoledronic acid (ZA), which is one of the most potent and efficacious bisphosphonates, has
been commonly used in clinical practice for the treatment of various bone disorders. The …

Background: Bisphosphonates are potent inhibitors of bone resorption. These kinds of
drugs, which are used for the treatment of osteolytic diseases, have been associated with …

J Oral Pathol Med (2012) 41: 713–720 Background: Zoledronic acid (ZA) is prescribed to
treat various metabolic bone diseases. Despite its efficacy in preventing bone loss, ZA has …

Objective: To establish a rat model of bisphosphonate-related osteonecrosis of the jaw
(BRONJ) that realistically mimics major clinical manifestations of the disease. Methods …

Oral Diseases (2011) 17, 291–297 Objective: Osteonecrosis of the jaw is a serious
complication of bisphosphonate treatment for which the pathophysiology is unknown. The …

J Oral Pathol Med (2012) 41: 788–792 Background: Osteonecrosis of the jaw (ONJ) is a
chronic complication of bisphosphonate therapy, mainly when intravenous, in cancer …

Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of
the long-term administration of BPs. The development of BRONJ is associated with the cell …

Objective This study aimed to check the effect of zoledronic acid (ZA) at subtoxic dose on
human osteoblasts (HOs) in terms of cell viability, apoptosis occurrence, and differentiation …

Purpose The aim was to assess the effect of a relevant regimen of zoledronic acid (ZA)
treatment for the study of bisphosphonate-related osteonecrosis of the jaw on alveolar bone …

Objectives Bisphosphonates-related osteonecrosis of the jaw (BRONJ) is a common
problem in patients undergoing long-term administration of highly potent nitrogen-containing …