Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

A stringent structure-activity relationship among polychlorinated biphenyls (PCBs)
possessing two or moreortho-chlorine substituents is observed for activation of ryanodine …

Ryanodine receptor isoforms are expressed in both excitable and nonexcitable tissues
where they form microsomal Ca2+ release channels broadly involved in shaping cellular …

There is mounting evidence that perinatal exposure to ortho-substituted PCB congeners
causes neurobehavioral and neurochemical alterations. The molecular mechanism for these …

Background: Aroclor 1254 (A1254) interferes with normal dendritic growth and plasticity in
the developing rodent brain, but the mechanism (s) mediating this effect have yet to be …

We recently reported that rats exposed to PCBs and MeHg during development were
impaired on the rotating rod, a test of balance and coordination that is often indicative of …

We recently demonstrated that polychlorinated biphenyl (PCB) congeners with multiple
ortho chlorine substitutions sensitize ryanodine receptors (RyRs), and this activity promotes …

Polychlorinated biphenyls (PCBs) with unsymmetrical chlorine substitutions and multiple
ortho-substitutions that restrict rotation around the biphenyl bond may exist in two stable …

Non–dioxin-like (NDL) polychlorinated biphenyls (PCBs) are widespread environmental
contaminants linked to neuropsychological dysfunction in children. NDL PCBs increase …

Ortho-substituted polychlorinated biphenyls (PCBs) have been shown to alter microsomal
Ca2+ transport by selective interaction with ryanodine receptors (RyRs) of muscle …