Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated “CpG
motifs” stimulate an innate immune response characterized by the production of cytokines …

Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG
motifs stimulate a strong innate immune response. This stimulation can be abrogated by …

Immune stimulation has been widely recognized as an undesirable side effect of certain
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …

Several types of immune cells possess pattern recognition receptors (PRR) that can
distinguish prokaryotic DNA from vertebrate DNA by detecting unmethylated CpG …

Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …

Oligonucleotide sequences containing unmethylated cytidine phosphate guanosine (CpG)
motifs are known to have significant immunostimulatory properties. Because of these …

Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …

Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …

Vertebrate immune systems have evolved the ability to detect and be activated by most
microbial and viral DNAs by virtue of their content of unmethylated 'CpG motifs', which are …

The DNA of bacteria and many viruses contain unmethylated CpG dinucleotides in particular
sequence contexts that activate vertebrate immune cells. A subset of these CpG motifs was …