Regulation of CpG‐induced immune activation by suppressive oligodeoxynucleotides

DM Klinman, R Zeuner, H Yamada… - Annals of the New …, 2003 - Wiley Online Library
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated “CpG
motifs” stimulate an innate immune response characterized by the production of cytokines …

Effect of suppressive DNA on CpG-induced immune activation

H Yamada, I Gursel, F Takeshita, J Conover… - The Journal of …, 2002 - journals.aai.org
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG
motifs stimulate a strong innate immune response. This stimulation can be abrogated by …

Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

AM Krieg - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1999 - Elsevier
Immune stimulation has been widely recognized as an undesirable side effect of certain
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …

From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA

AM Krieg - Antisense and Nucleic Acid Drug Development, 2001 - liebertpub.com
Several types of immune cells possess pattern recognition receptors (PRR) that can
distinguish prokaryotic DNA from vertebrate DNA by detecting unmethylated CpG …

Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.

KJ Ishii, I Gursel, M Gursel… - Current opinion in …, 2004 - europepmc.org
Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …

Beyond danger: unmethylated CpG dinucleotides and the immunopathogenesis of disease

B Goldberg, HB Urnovitz, RB Stricker - Immunology letters, 2000 - Elsevier
Oligonucleotide sequences containing unmethylated cytidine phosphate guanosine (CpG)
motifs are known to have significant immunostimulatory properties. Because of these …

[HTML][HTML] CpG DNA: recognition by and activation of monocytes

DM Klinman, F Takeshita, I Gursel, C Leifer, KJ Ishii… - Microbes and …, 2002 - Elsevier
Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune
response characterized by the activation of Ig-and cytokine-secreting cells. Synthetic …

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine …

ER Kandimalla, L Bhagat, D Wang, D Yu… - Nucleic Acids …, 2003 - academic.oup.com
Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …

Direct immunologic activities of CpG DNA and implications for gene therapy

AM Krieg - The journal of gene medicine, 1999 - Wiley Online Library
Vertebrate immune systems have evolved the ability to detect and be activated by most
microbial and viral DNAs by virtue of their content of unmethylated 'CpG motifs', which are …

Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs

H ZHAO, SH CHENG, NS YEW - Antisense and Nucleic Acid Drug …, 2000 - liebertpub.com
The DNA of bacteria and many viruses contain unmethylated CpG dinucleotides in particular
sequence contexts that activate vertebrate immune cells. A subset of these CpG motifs was …