Angiotensin-converting enzyme 2 (ACE2) is present in the heart and thought to exert
protective functions. We conducted studies in ACE2 deficient mice to determine whether …

Abstract Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1–7 thereby
negatively regulating the renin-angiotensin system. However, heart disease in humans and …

Angiotensin-converting enzyme (ACE) 2 is a key negative regulator of the renin–angiotensin
system and metabolizes angiotensin II (Ang II) into Ang 1 to 7. Ang II is a vasoactive peptide …

Background Angiotensin‐converting enzyme 3 (ACE 3) is a recently defined homolog of
ACE. However, the pathophysiological function of ACE 3 is largely unknown. Here, we aim …

Angiotensin-converting enzyme type 2 (ACE2) has been shown to be an important member
of the renin angiotensin system. Previously, we observed that central ACE2 reduces the …

Angiotensin converting enzyme 2 (ACE2) has been linked to cardiac dysfunction and
hypertension-induced cardiac pathophysiology. In this study, we used a gene …

The renin-angiotensin (Ang) system plays a critical role in the regulation of blood pressure,
body fluid, electrolyte homeostasis, and organ remodeling under physiological and …

Background—Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that
metabolizes Ang II into Ang 1-7, thereby functioning as a negative regulator of the renin …

Objectives The peptidase action of angiotensin converting enzyme 2 (ACE2) allows it to
function as a negative regulator of the renin–angiotensin system. Current …

Background—Angiotensin-converting enzyme 2 (ACE2) is a pleiotropic
monocarboxypeptidase capable of metabolizing several peptide substrates. We …